An efficient transformation of primary halides into nitriles through palladium-catalyzed hydrogen transfer reaction.
نویسندگان
چکیده
Two-step one-pot transformation of primary halides into corresponding nitriles is successfully achieved. Nucleophilic substitution of primary halides with sodium azide and subsequent palladium-catalyzed hydrogen transfer proceeds smoothly in the presence of sterically bulky ligand dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine (XPhos) in acetone to produce nitriles in satisfactory to good yields.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 53 شماره
صفحات -
تاریخ انتشار 2015